| Children |
| | 1. Mary Esther MIDDLETON, b. 13 Jul 1820 |
| | 2. Elizabeth MIDDLETON, b. 24 May 1822 d. 1903 (Age 80 years) |
| | 3. Cleland Kinloch MIDDLETON, b. 16 Aug 1824 d. 4 May 1876 (Age 51 years) |
| | 4. Isabella MIDDLETON, b. 30 May 1826 d. 14 Nov 1912, Charleston, Charleston County, South Carolina (Age 86 years) |
| | 5. Harriett MIDDLETON, b. 26 Feb 1828 |
| | 6. Henry Augustus MIDDLETON, Jr., b. 24 Nov 1829 d. 27 Jul 1861, Battle of Manassas, Virginia (Age 31 years) |
| | 7. Anne Manigault MIDDLETON, b. 24 Aug 1831 |
| | 8. Arthur MIDDLETON, b. 25 Jun 1833 d. 1 Sep 1857 (Age 24 years) |
| | 9. Francis Kinloch MIDDLETON, b. 15 Jun 1835 d. 30 May 1864, Battle of Hawes Shop (Age 28 years) |
| | 10. Alicia MIDDLETON, b. 4 Sep 1840 |
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